Deep and quantitative top-down proteomics in clinical and translational research

作者:Kelleher Neil L*; Thomas Paul M; Ntai Ioanna; Compton Philip D; LeDuc Richard D
来源:Expert Review of Proteomics, 2014, 11(6): 649-651.
DOI:10.1586/14789450.2014.976559

摘要

It has long been understood that it is proteins, expressed and post-translationally modified, that are the primary regulators of both the fate and the function of cells. The ability to measure differences in the expression of the constellation of unique protein forms (proteoforms) with complete molecular specificity has the potential to sharply improve the return on investment for mass spectrometry-based proteomics in translational research and clinical diagnostics.