A CONVENIENT METHOD FOR THE SYNTHESIS OF 1-R-1,2,3,4-TETRAHYDROBENZOTHIENO[2,3-c]PYRIDINE DERIVATIVES

作者：Tolkunov V S; Eresko A B; Mazepa A V; Tolkunov S V^*

来源：Chemistry of Heterocyclic Compounds, 2011, 47(9): 1170-1175.

• 2-(1-benzothiophen-3-yl)ethylamine
• 1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine
• triisopropylchlorosilane
• Pictet-Spengler reaction

New 1-R-2-methyl-1,2,3,4-tetrahydrobenzothieno[2,3-c]pyridine derivatives have been obtained by cyclization of 2-(1-benzothiophen-3-yl)ethylamines with aromatic and heteroaromatic aldehydes in the presence of triisopropylchlorosilane.

• 出版日期2011-11