Botulinum toxin for hereditary spastic paraplegia: effects on motor and non-motor manifestations

作者：Servelhere Katiane R; Faber Ingrid; Martinez Alberto; Nickel Renato; Moro Adriana; Germiniani Francisco M B; Moscovich Mariana; Blume Tatiane R; Munhoz Renato P; Teive Helio A G; Franca Marcondes C Jr^*

来源：Arquivos de Neuro-Psiquiatria, 2018, 76(3): 183-188.

DOI：10.1590/0004-282X20180013

• botulinum toxin
• spastic paraplegia
• hereditary
• muscle spasticity

Motor and non-motor manifestations are common and disabling features of hereditary spastic paraplegia (HSP). Botulinum toxin type A (Btx-A) is considered effective for spasticity and may improve gait in these patients. Little is known about the effects of Btx-A on non-motor symptoms in HSP patients. Objective: To assess the efficacy of Btx-A on motor and non-motor manifestations in HSP patients. Methods: Thirty-three adult patients with a clinical and molecular diagnosis of HSP were evaluated before and after Btx-A injections. Results: Mean age was 41.7 +/- 13.6 years and there were 18 women. Most patients had a pure phenotype and SPG4 was the most frequent genotype. The Btx-A injections resulted in a decrease in spasticity at the adductor muscles, and no other motor measure was significantly modified. In contrast, fatigue scores were significantly reduced after Btx-A injections. Conclusion: Btx-A injections resulted in no significant functional motor improvement for HSP, but fatigue improved after treatment.

• 出版日期2018-3