科研之友
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摘要
A new domino process of three-component Povarov reaction and aerobic dehydrogenation was developed toward the synthesis of polysubstituted quinolines. 2,4-Disubstituted-8-nitroquinolines, which are important precursors for the synthesis of antimalarial primaquine drug-like molecules, were prepared conveniently by this method in moderate to good yields. Bronsted acid (HClO(4))-modified montmorillonite was found to be a crucial catalyst in promoting the procedure.
- 出版日期2009-12-9
