A Possible Link Between Rheumatoid Arthritis and Periodontitis: A Systematic Review and Meta-analysis

作者：Tang, Qingqin; Fu, Haitao; Qin, Baodong; Hu, Zhide; Liu, Yaoting; Liang, Yan; Zhou, Lin; Yang, Zaixing^*; Zhong, Renqian^*

来源：International Journal of Periodontics and Restorative Dentistry, 2017, 37(1): 79-86.

DOI：10.11607/prd.2656

• PORPHYROMONAS-GINGIVALIS
• ASSOCIATION
• DISEASE
• SEVERITY
• DEFINITIONS
• RISK

Previous studies have shown that patients with rheumatoid arthritis (RA) have a higher susceptibility to periodontitis, but the results of individual studies remain controversial. The aim of the present meta-analysis was to comprehensively evaluate the association between RA and periodontitis. A systematic literature search was conducted in PubMed and EMBASE. Data were extracted using standardized forms, and odds ratios (OR) with 95% confidence intervals (C) were calculated for each study. Pooled data were estimated by fixed-and randomeffects models if appropriate. Eight case-control studies were included in the present study. Study size ranged from 104 to 151,569 participants. The prevalence of periodontitis in RA patients ranged from 15.5% to 100%, compared with 10.0% to 82.1% in controls. In group 1 (control) and group 2, the heterogeneity was 38% and 11%, respectively. Using fixed-effects analysis, the overall pooled estimates of the ORs for periodontitis were 4.68 (95% CI: 3.11-705) and 1.28 (95% Cl: 1.24-1.33) in groups 1 and 2, respectively. This meta-analysis indicates that RA was significantly associated with increased overall risk of periodontitis.

• 出版日期2017-2
• 单位中国人民解放军第二军医大学; 天津市中医药研究院附属医院