Alternating stereoselective self-assembly of SSSS/RRRR or RSSR isomers of tetrakisphosphines in the row of 14-, 16-, 18-and 20-membered macrocycles

作者：Naumov Roman N^*; Musina Elvira I; Kanunnikov Kirill B; Fesenko Tatiana I; Krivolapov Dmitry B; Litvinov Igor A; Lonnecke Peter; Hey Hawkins Evamarie; Karasik Andrey A; Sinyashin Oleg G

来源：Dalton Transactions, 2014, 43(33): 12784-12789.

DOI：10.1039/c4dt01619j

Novel 18- and 20-membered P,N-macrocycles have been obtained stereoselectively by covalent self-assembly of alpha,omega-bisphosphines, formaldehyde and benzylamine. Alternating SSSS/RRRR or RSSR diastereomers were formed in the row of the 14-, 16-, 18- and 20-membered macrocyclic aminomethylphosphines. For the first time it was demonstrated that the stereochemical result of the reaction depends on the even or odd number of the methylene groups between the two chiral phosphorus atoms in the initial alpha,omega-bisphosphines.

• 出版日期2014-9-7