Ultrafast Killing and Self-Gelling Antimicrobial Imidazolium Oligomers

作者：Riduan Siti Nurhanna; Yuan Yuan; Zhou Feng; Leong Jiayu; Su Haibin^*; Zhang Yugen^*

来源：Small, 2016, 12(14): 1928-1934.

DOI：10.1002/smll.201600006

• antimicrobial materials
• fast-killing
• molecular dynamics
• self-gelling
• cell membrane

Infectious diseases and the increasing threat of worldwide pandemics have underscored the importance of antibiotics and hygiene. Intensive efforts have been devoted to developing new antibiotics to meet the rapidly growing demand. In particular, advancing the knowledge of the structure-property-activity relationship is critical to expedite the design and development of novel antimicrobial with the needed potential and efficacy. Herein, a series of new antimicrobial imidazolium oligomers are developed with the rational manipulation of terminal group's hydrophobicity. These materials exhibit superior activity, excellent selectivity, ultrafast killing (>99.7% killing within 30 s), and desirable self-gelling properties. Molecular dynamic simulations reveal the delicate effect of structural changes on the translocation motion across the microbial cell membrane. The energy barrier of the translocation process analyzed by free energy calculations provides clear kinetic information to suggest that the spontaneous penetration requires a very short timescale of seconds to minutes for the new imidazolium oligomers.

• 出版日期2016-4-13
• 单位南阳理工学院