N-phosphoryl amino acids and biomolecular origins

作者：Cheng CM; Liu XH; Li YM; Ma Y; Tan B; Wan R; Zhao YF^*

来源：Origins of Life and Evolution of the Biosphere, 2004, 34(5): 455-464.

DOI：10.1023/B:ORIG.0000043122.97856.79

• N-phosphoryl amino acid
• conjugate of amino acid and nucleoside
• origin of life
• phosphorus chemistry
• penta-coordinate phosphorus compounds

The possible role of phosphoryl amino acids for biomolecular origins is briefly reviewed. Peptide formation, ester formation, ester exchange on phosphorus and N to O migration occurred when the N-phosphoryl amino acid was incubated at room temperature. Short nucleotides and peptides were formed when nucleoside was reacted with N-phosphoryl amino acid at room temperature. Serine and threonine residues in their conjugate with different nucleosides ( mediated with phosphorus) showed different self-cleavage activities. N-phosphoryl Histine and Ser-His dipeptide could cleave nucleic acids, proteins and esters in neutral medium. Based on a simple model, a pathway of ';co-evolution of protein and nucleic acid'; was proposed.

• 出版日期2004-10
• 单位清华大学