An Organocatalytic Access to Spiro[4.5]decanes and Spiro[4.6]undecanes Containing Aminolactones and 3-Aminopyrrolidines

作者：Cormier Morgan; Chardon Aurelien; Blanchet Jerome; Rouden Jacques; Maddaluno Jacques; De Paolis Michael^*

来源：Synthesis (Germany), 2015, 47(17): 2549-2553.

DOI：10.1055/s-0034-1380146

• Mannich reaction
• spiro[4
• 5]decanes
• spiro[4
• 6]undecanes
• aminolactones
• 3-aminopyrrolidines

The organocatalyzed Mannich coupling of cyclic carboxaldehydes allowed the concise and simple preparation of spirocyclic aminolactones. Their conversion into pharmaceutically relevant spiro[4.5]cyclic and spiro[4.6]cyclic 3-aminopyrrolidines is also described.

• 出版日期2015-9