Anti-Inflammatory Polyoxygenated Steroids from the Soft Coral Sinularia sp.

作者：Su, Jui Hsin; Lo, Ching Li; Lu, Yi; Wen, Zhi Hong; Huang, Chiung Yao; Dai, Chang Feng; Sheu, Jyh Horng^*

来源：Bulletin of the Chemical Society of Japan, 2008, 81(12): 1616-1620.

DOI：10.1246/bcsj.81.1616

Four new polyhydroxylated steroids (1-4) were isolated from a Formosan soft coral Sinularia sp. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and I D and 2D NMR) analyses. Among these metabolites, 3 and 4 are rarely found marine steroids with a C-9/C-10 double bond. Compounds I and 2 have shown significant inhibition of the accumulation of the pro-inflammatory COX-2 protein of LPS-stimulated RAW264.7 macrophage cells at 10 mu M.

• 出版日期2008-12-15
• 单位中山大学