A Novel Hybrid Plasmid Carrying Multiple Antimicrobial Resistance and Virulence Genes in Salmonella enterica Serovar Dublin

作者：Mangat Chand S; Bekal Sadjia; Irwin Rebecca J; Mulvey Michael R

来源：Antimicrobial Agents and Chemotherapy, 2017, 61(6): e02601-16.

DOI：10.1128/AAC.02601-16

<jats:title>ABSTRACT</jats:title>
<jats:p>
Virulence plasmids and antibiotic resistance plasmids are usually maintained separately in
<jats:named-content content-type="genus-species">Salmonella</jats:named-content>
spp.; however, we report an instance of a hybrid plasmid (pN13-01125) in
<jats:named-content content-type="genus-species">Salmonella enterica</jats:named-content>
serovar Dublin. Review of the complete sequence of the 172,265-bp plasmid suggests that pN13-01125 is comprised of the previously described pSDVr and pSH696_135 plasmids and that the mechanism of hybridization likely involves IS
<jats:italic>6</jats:italic>
(IS
<jats:italic>26</jats:italic>
) insertion sequence elements. The plasmid has a low conjugation frequency, confers resistance to six classes of antimicrobials, and contains a complete
<jats:italic>spv</jats:italic>
virulence operon.
</jats:p>

• 出版日期2017-6
• 单位Public Health Agency of Canada