Multi-Residues Analysis of Volatile Organic Solvents in Cefotaxime Products by Capillary Gas Chromatography

作者：Yan H; Qiao F; Tian M; Row K H^*

来源：Asian Journal of Chemistry, 2011, 23(7): 2965-2968.

• Capillary gas chromatography
• Residual organic solvents
• Cefotaxime
• Acetone
• Isopropanol

A newly simple and sensitive method was established:for the multi-residues analysis of two volatile organic solvents, acetone and isopropanol, in cefotaxime products by capillary gas chromatography with n-propanol as the internal standard material. A PEG-20M flexible fused quartz capillary column (30 m x 0.25 mm x 0.33 mu m) was used as the analysis column with nitrogen carrier gas and FID detector. A variety of influencing factors for separation and detection of these volatile organic solvents were investigated and optimized. Good linearity were obtained in a range of 0.4-200 mu g/mL with the correlation coefficients (r(2)) of 0.9991 for acetone, 0.9993 for isopropanol. The average recoveries of acetone and isopropanol in three different Spiked concentrations were ranged from 92.7-103.2 % with the relative standard deviation less than 3.5 % (n = 5). The proposed method was successfully applied for determination of acetone and isopropanol residues in different cefotaxime products with satisfied result. This method offers a good alternative for routine analysis due to its simplicity and reliability.

• 出版日期2011-7
• 单位保定学院