A covalent G-site inhibitor for glutathione S-transferase Pi (GSTP(1-1))

作者：Shishido Yuko; Tomoike Fumiaki; Kimura Yasuaki; Kuwata Keiko; Yano Takato; Fukui Kenji; Fujikawa Haruka; Sekido Yoshitaka; Murakami Tonami Yuko; Kameda Tomoshi; Shuto Satoshi; Abe Hiroshi^*

来源：Chemical communications, 2017, 53(81): 11138-11141.

DOI：10.1039/c7cc05829b

We herein report the first covalent G-site-binding inhibitor for GST, GS-ESF (1), which irreversibly inhibited the GSTP1-1 function. LC-MS/MS and X-ray structure analyses of the covalently linked GST-inhibitor complex suggested that 1 reacted with Tyr108 of GSTP1-1. The mechanism of covalent bond formation was discussed based on MD simulation results.

• 出版日期2017-10-18