A simple spectrophotometric procedure for determination of valaciclovir in dosage forms and biological fluids

作者：Tarinc Derya^*; Golcu Aysegul

来源：Journal of Analytical Chemistry, 2013, 68(1): 27-32.

DOI：10.1134/S106193481301005X

• spectrophotometry
• biological fluids

A simple and selective spectrophotometric procedure for the determination of Valaciclovir (VALA) is proposed and applied to determine the substance in tablets and biological fluids. This procedure is proposed for the determination of VALA in Britton-Robinson (BR) buffer at pH 6.0, which allows quantification over the 4 x 10(-6) to 6 x 10(-5) M range for spectrophotometric measurements. The repeatability and reproducibilty of the procedure for serum and breast milk samples are estimated. Precision and accuracy are also checked. The standard additions method is used for biological fluids. The proposed produce was verified for the determination of VALA in real human serum, breast milk samples; the selectivity over the metabolites was found to be quite satisfactory.

• 出版日期2013-1