Highly Regioselective Arylation of 1,2,3-Triazole N-Oxides with Sodium Arenesulfinates via Palladium-Catalyzed Desulfitative Cross-Coupling Reaction

作者：Zhu, Jiayi; Chen, Yu; Lin, Feng; Wang, Baoshuang; Huang, Qing^*; Liu, Liangxian

来源：Synlett, 2015, 26(8): 1124-1130.

DOI：10.1055/s-0034-1380186

• palladium
• 1
• 2
• 3-triazole N-oxide
• arylation
• sodium arylsulfinate

A convenient and highly regioselective palladium-catalyzed direct C5-arylation of 1,2,3-triazole N-oxides was developed in the presence of silver carbonate and tripotassium phosphate. This protocol allowed use of sodium arylsulfinates, diphenylphosphine oxide, and triphenylphosphine as arylating reagents to produce 2-aryl-5-aryl-1,2,3-triazole N-oxides in good to excellent yields, providing a complement to the existing methods for the direct arylation of 1,2,3-triazole N-oxides.

• 出版日期2015-5
• 单位赣南师范大学