A new neuroprotective bakkenolide from the rhizome of Petasites tricholobus

作者：Zhang Na; Guo Mei Li^*; Zhang Ge; Li Run Ping

来源：Chinese Chemical Letters, 2008, 19(7): 841-844.

DOI：10.1016/j.cclet.2008.04.036

• Petasites tricholobus
• Compositae
• Bakkenolide-Va
• Neuroprotection

A new bakkenolide-type compound, bakkenolide-Va(1), was isolated from the rhizome of Petasites tricholobus. The structure was characterized on the basis of various NMR((1)H, (13)C, (1)H-(1)H COSY, HMQC, HMBC and NOESY) and mass spectrometry data. The neuroprotective activity of bakkenolide-Va was investigated in primarily cultured neurons treated by hypoxia-glucose deprivation and various types of oxidative insults.

• 出版日期2008-7
• 单位中国人民解放军第二军医大学