Novel neomycin sulfate-loaded hydrogel dressing with enhanced physical dressing properties and wound-curing effect

作者：Choi Jong Seo; Kim Dong Wuk; Kim Dong Shik; Kim Jong Oh; Yong Chul Soon; Cho Kwan Hyung; Youn Yu Seok; Jin Sung Giu^*; Choi Han Gon^*

来源：Drug Delivery, 2016, 23(8): 2806-2812.

DOI：10.3109/10717544.2015.1089958

• Histological examination
• hydrogel dressing
• neomycin sulfate
• polyvinyl alcohol
• polyvinyl pyrrolidone
• sodium alginate
• wound-curing effect

To develop a novel neomycin sulfate-loaded hydrogel dressing (HD), numerous neomycin sulfate-loaded HDs were prepared with various amounts of polyvinyl alcohol (PVA), polyvinyl pyrrolidone (PVP) and sodium alginate (SA) using freeze-thawing technique, and their physical dressing properties, drug release, in vivo wound curing and histopathology in diabetic-induced rats were assessed. SA had a positive effect on a swelling capacity, but a negative effect on the physical dressing properties and drug release of HD. However, PVP did the opposite. In particular, the neomycin sulfate-loaded HD composed of drug, PVA, PVP and SA at the weight ratio of 1/10/0.8/0.8 had excellent swelling and bioadhesive capacity, good elasticity and fast drug release. Moreover, this HD gave more improved wound curing effect compared to the commercial product, ensured the disappearance of granulation tissue and recovered the wound tissue to normal. Therefore, this novel neomycin sulfate-loaded HD could be an effective pharmaceutical product for the treatment of wounds.

• 出版日期2016-10