A der(1;15)(q10;q10) is a rare nonrandom whole-arm translocation in patients with acute lymphoblastic leukemia

作者：Park Tae Sung; Song Jaewoo; Lee Kyung A; Lee Sang Guk; Yoon Seoyoung; Kim Jin Seok; Lyu Chuhl Joo; Choi Jong Rak^*

来源：Cancer Genetics and Cytogenetics, 2007, 179(2): 132-135.

DOI：10.1016/j.cancergencyto.2007.08.008

A rare karyotypic event, der(1;15)(q10;q10), which involves the whole long arms of chromosomes 1 and 15, has been reported in patients with various conditions, including acute myelogenous leukemia, myelodysplastic syndrome, polycythemia vera, and multiple myeloma. Only 27 cases of unbalanced der(1;15)(q10;q10) have been documented in the literature as single or complexed chromosomal abnormalities in hematological malignancies. Here, we describe two cases of acute lymphoblastic leukemia with der(1;15)(q10;q10), and review the previous reports. Although more case studies are needed, we suggest that der(1;15)(q10;q10) should be considered a nonrandont chromosomal abnormality in hematological malignancies including both lymphoid and myeloid neoplasms.

• 出版日期2007-12