New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells' State of Competence

作者：Plikus Maksim V^*

来源：Journal of Investigative Dermatology, 2012, 132(5): 1321-1324.

DOI：10.1038/jid.2012.38

The timing mechanism of the hair cycle remains poorly understood. However, it has become increasingly clear that the telogen-to-anagen transition is controlled jointly by at least the bone morphogenic protein (BMP), WNT, fibroblast growth factor (FGF), and transforming growth factor (TGF)-beta signaling pathways. New research shows that Fgf18 signaling in hair follicle stem cells synergizes BMP-mediated refractivity, whereas Tgf-beta 2 signaling counterbalances it. Loss of Fgf18 signaling markedly accelerates anagen initiation, whereas loss of Tgf-beta 2 signaling significantly delays it, supporting key roles for these pathways in hair cycle timekeeping.

• 出版日期2012-5