Adaptive and regulatory mechanisms in aged rats with postoperative cognitive dysfunction

作者：Bi, Yanlin; Liu, Shuyun; Yu, Xinjuan; Wang, Mingshan; Wang, Yuelan^*

来源：Neural Regeneration Research, 2014, 9(5): 534-539.

DOI：10.4103/1673-5374.130084

• nerve regeneration
• postoperative cognitive dysfunction
• splenectomy
• brain
• aging
• 5 ' adenosine monophosphate-activated protein kinase
• nuclear factor-kappa B
• tumor necrosis factor-alpha
• interleukin-1 beta
• neural regeneration

Inflammation may play a role in postoperative cognitive dysfunction. 5 ' Adenosine monophosphate-activated protein kinase, nuclear factor-kappa B, interleukin-1 beta, and tumor necrosis factor-a are involved in inflammation. Therefore, these inflammatory mediators may be involved in postoperative cognitive dysfunction. Western immunoblot analysis revealed 5' adenosine monophosphate-activated protein kinase and nuclear factor-kappa B in the hippocampus of aged rats were increased 1-7 days after splenectomy. Moreover, interleukin-1 beta and tumor necrosis factor-a were upregulated and gradually decreased. Therefore, these inflammatory mediators may participate in the splenectomy model of postoperative cognitive dysfunction in aged rats.

• 出版日期2014-3
• 单位绍兴市人民医院; 山东省千佛山医院; 青岛市市立医院; 山东大学