A Fully Automated Radiosynthesis of [F-18]Fluoroethyl-Diprenorphine on a Single Module by Use of SPE Cartridges for Preparation of High Quality 2-[F-18]Fluoroethyl Tosylate

作者：Schoultz Bent W^*; Reed Brian J; Marton Janos; Willoch Frode; Henriksen Gjermund

来源：Molecules, 2013, 18(6): 7271-7278.

DOI：10.3390/molecules18067271

• 2-[F-18]fluoroethyl tosylate
• F-18-fluoroalkylation
• PET
• opioid receptors
• automation
• solid phase extraction

We have developed a new method for automated production of 2-[F-18]fluoroethyl tosylate ([F-18]FETos) that enables F-18-alkylation to provide PET tracers with high chemical purity. The method is based on the removal of excess ethylene glycol bistosylate precursor by precipitation and subsequent filtration and purification of the filtrate by means of solid phase extraction cartridges (SPE). The method is integrated to a single synthesis module and thereby provides the advantage over previous methods of not requiring HPLC purification, as demonstrated by the full radiosynthesis of the potent opioid receptor PET tracer [F-18]fluoroethyldiprenorphine.

• 出版日期2013-6