New fibrous sheath anomaly in spermatozoa of men with consanguinity

作者：Escalier Denise^*; Albert Martine

来源：Fertility and Sterility, 2006, 86(1): 219.e1.

DOI：10.1016/j.fertnstert.2005.12.042

• Consanguinity
• fibrous sheath
• flagellum
• motility
• sperm
• spermatozoa

Objective: The cause of the sperm motility impairment was investigated in infertile men.
Design: Case report.
Setting: University-based andrology laboratory.
Patients: Two unrelated consanguineous patients.
Intervention(s): None.
Main Outcome Measure(s): The sperm flagella lengths were measured using quantitative analysis software and their ultrastructural anomalies were quantitatively recorded.
Result(s): A total of 67.5% of the flagella were truncated, and 100% lacked the medium region of the ribs of the fibrous sheath.
Conclusion(s): The data suggested a morphogenetic anomaly at the stage where rib precursors are formed during spermiogenesis. The consanguinity of these patients suggested a genetic origin for this newly discovered anomaly of the human sperm's fibrous sheath. The family tree appears to indicate an autosomal recessive inheritance. (Fertil Steril (R) 2006;86:219.e1-9.

• 出版日期2006-7