Stability of underdominant genetic polymorphisms in population networks

作者：Laruson Aki J; Reed Floyd A^*

来源：Journal of Theoretical Biology, 2016, 390: 156-163.

DOI：10.1016/j.jtbi.2015.11.023

• Underdominance
• Coordination game
• Network topology
• Dynamical system
• Population genetics

Heterozygote disadvantage is potentially a potent driver of population genetic divergence. Also referred to as underdominance, this phenomena describes a situation where a genetic heterozygote has a lower overall fitness than either homozygote. Attention so far has mostly been given to underdominance within a single population and the maintenance of genetic differences between two populations exchanging migrants. Here we explore the dynamics of an underdominant system in a network of multiple discrete, yet interconnected, populations. Stability of genetic differences in response to increases in migration in various topological networks is assessed. The network topology can have a dominant and occasionally non-intuitive influence on the genetic stability of the system.

• 出版日期2016-2-7