Dependence as a unifying construct in defining Alzheimer's disease severity

作者：McLaughlin Trent; Feldman Howard; Fillit Howard; Sano Mary; Schmitt Frederick; Aisen Paul; Leibman Christopher^*; Mucha Lisa; Ryan J Michael; Sullivan Sean D; Spackman D Eldon; Neumann Peter J; Cohen Joshua; Stern Yaakov

来源：Alzheimer's and Dementia, 2010, 6(6): 482-493.

DOI：10.1016/j.jalz.2009.09.004

• Alzheimer's disease
• Dementia
• Functional impairment
• Dependence
• Disease progression

This article reviews measures of Alzheimer's disease (AD) progression in relation to patient dependence and offers a unifying conceptual framework for dependence in AD Clinicians typically characterize AD by symptomatic impairments in three domains cognition function and behavior From a patient's perspective changes in these domains, individually and in concert, ultimately lead to increased dependence and loss of autonomy Examples of dependence in AD range from a need for reminders (early AD) to requiring safety supervision and assistance with basic functions (late AD) Published literature has focused on the clinical domains as somewhat separate constructs and has given limited attention to the concept of patient dependence as a descriptor of AD progression This article presents the concept of dependence on others for care needs as a potential

• 出版日期2010-11