A novel natural compound from garlic (Allium sativum L.) with therapeutic effects against experimental polymicrobial sepsis

作者：Lee Sung Kyun; Park Yoo Jung; Ko Min Jung; Wang Ziyu; Lee Ha Young; Choi Young Whan; Bae Yoe Sik^*

来源：Biochemical and Biophysical Research Communications, 2015, 464(3): 774-779.

DOI：10.1016/j.bbrc.2015.07.031

• Sepsis
• Sucrose methyl 3-formyl-4-methylpentanoate
• Bacteria killing
• Inflammation

Sepsis is a serious, life-threatening, infectious disease. In this study, we demonstrate that sucrose methyl 3-formyl-4-methylpentanoate (SMFM), a novel natural compound isolated from garlic (Allium sativum L.), markedly enhances survival rates by inhibiting lung inflammation in a cecal ligation and puncture (CLP) experimental polymicrobial sepsis model. SMFM strongly reduced bacterial colony units from peritoneal fluid in CLP mice by stimulating the generation of reactive oxygen species. Lymphocyte apoptosis in spleens from CLP mice was also markedly decreased by SMFM administration. SMFM also significantly inhibited the production of proinflammatmy cytokines, such as TNF-alpha, interleukin-1 beta (IL-1 beta) and IL-6, in CLP mice. Lipopolysaccharide-stimulated production of TNF-a and IL-6 were also strongly inhibited by SMFM in mouse bone marrow-derived macrophages. Taken together, our results indicate that SMFM has therapeutic effects against polymicrobial sepsis that are mediated by enhanced microbial killing and blockage of cytokine storm.

• 出版日期2015-8-28