Middle East Respiratory Syndrome Coronavirus Spike Protein Delivered by Modified Vaccinia Virus Ankara Efficiently Induces Virus-Neutralizing Antibodies

作者：Song Fei; Fux Robert; Provacia Lisette B; Volz Asisa; Eickmann Markus; Becker Stephan; Osterhaus Albert D M E; Haagmans Bart L; Sutter Gerd^*

来源：Journal of Virology, 2013, 87(21): 11950-11954.

DOI：10.1128/JVI.01672-13

Middle East respiratory syndrome coronavirus (MERS-CoV) has recently emerged as a causative agent of severe respiratory disease in humans. Here, we constructed recombinant modified vaccinia virus Ankara (MVA) expressing full-length MERS-CoV spike (S) protein (MVA-MERS-S). The genetic stability and growth characteristics of MVA-MERS-S make it a suitable candidate vaccine for clinical testing. Vaccinated mice produced high levels of serum antibodies neutralizing MERS-CoV. Thus, MVA-MERS-S may serve for further development of an emergency vaccine against MERS-CoV.

• 出版日期2013-11