ANTIBACTERIAL, ANTIOXIDANT AND BINDING STUDIES OF SOME NOVEL DIARYL SULPHIDE DERIVATIVES

作者：Moosun Salma; Joule John A; Bhowon Minu G; Jhaumeer Laulloo Sabina^*

来源：Phosphorus, Sulfur, and Silicon and the Related Elements, 2012, 187(11): 1383-1400.

DOI：10.1080/10426507.2012.685996

• Diaryl sulphides
• benzamides
• antibacterial
• antioxidant
• binding constants

A series of novel acyclic and cyclic diaryl sulphides was synthesized from 2,2'-dithiobenzoic acid. The various diaryl sulphides were characterized by use of spectral (IR, H-1 and C-13 NMR, ESI/MS) and elemental analyses. The antimicrobial activities of the compounds were evaluated in terms of their minimum inhibition concentration (MIC) against a panel of clinical isolates bacteria and were found to possess only moderate antimicrobial activities. N, N'-Bis(2-hydroxyphenyl)-2,2'-thiodibenzamide (13), exhibiting a hydroxy group at the phenyl ring, was the most active antimicrobial agent within the series, with MIC values of 0.05 mg mL(-1) and 10 mg mL(-1) against Staphylococcus aureus and Bacillus cereus, respectively. The antioxidant efficiency of the diaryl sulphides was determined by 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity with 13 being the most active compound. The interaction of 2,2'-thiodibenzanilide, N,N'-bis(2-methylphenyl)-2,2'-thiodibenzamide, and N,N'-bis(2-hydroxyphenyl)-2,2'-thiobenzamide with guanine, glutamic acid, and urea were studied quantitatively with binding constants ranging from 1 x 10(3) M-1 to 2.7 x 10(4) M-1.

• 出版日期2012