DIRECT PERFLUORINATION OF AN ACID-SENSITIVE GLYCOL ETHER AS PRECURSOR FOR PERFLUORO(2-(METHOXYMETHOXY)ETHYL VINYL ETHER)

作者：Liu, Hongle; Pan, Xusong; Yuan, Lihua; Zou, Shuliang; Li, Peishen; Wang, Wei; He, Youzhou; Feng, Wen^*; Yang, Xiaoyong; Luo, Kai; Wu, Yong

来源：Synthetic Communications, 2012, 42(7): 959-966.

DOI：10.1080/00397911.2010.532578

• Acid-sensitive glycol ether
• fluorination
• perfluoro-vinyl ether

A four-step approach to perfluoro(2-(methoxymethoxy)ethyl vinyl ether) 5 from an acid-sensitive glycol ether 3 by liquid-phase direct fluorination (DF) has been described. The perfluoro precursor was achieved by control of the gradient increase of temperature (-20 degrees C to 15 degrees C) and addition of sodium fluoride. Improved workup with benzyl alcohol provided a convenient method for purification and a practical means for tracing the progress of fluorination.

• 出版日期2012
• 单位四川大学