Nerve, muscle and heart acute toxicity following oxaliplatin and capecitabine treatment

作者：Orsucci Daniele^*; Pizzanelli Chiara; Ali Greta; Calabrese Rosanna; Ricci Giulia; Lenzi Paola; Petrozzi Lucia; Moretti Policarpo; Siciliano Gabriele

来源：Neuromuscular Disorders, 2012, 22(8): 767-770.

DOI：10.1016/j.nmd.2012.04.004

• Mitochondria
• mtDNA
• Necrotizing myopathy
• Neurotoxicity
• Toxic myopathy
• Toxic neuropathy

Capecitabine plus oxaliplatin combination (XELOX) is the first-line treatment in metastatic colorectal cancer. Here we report a case of acute, severe but substantially reversible, neuromuscular and cardiac toxicity following XELOX chemotherapy. Muscle biopsy findings were consistent with a toxic myopathy with necrotizing features and vacuolar changes; COX-negative fibers were also present. The time course could support a main role for capecitabine, which may have some neurotoxic effects (more frequently central), but a detrimental interaction between the two drugs cannot be ruled out and further studies are needed.

• 出版日期2012-8