Depression, anxiety and alexithymia symptoms are major determinants of health related quality of life (HRQoL) in cirrhotic patients

作者：Nardelli Silvia; Pentassuglio Ilaria; Pasquale Chiara; Ridola Lorenzo; Moscucci Federica; Merli Manuela; Mina Concetta; Marianetti Massimo; Fratino Mariangela; Izzo Chiara; Merkel Carlo; Riggio Oliviero^*

来源：Metabolic Brain Disease, 2013, 28(2): 239-243.

DOI：10.1007/s11011-012-9364-0

• Psychometric evaluation
• Minimal hepatic encephalopathy
• Liver cirrhosis
• Health related quality of life
• Depression
• State and trait anxiety
• Alexithymia

HRQoL is impaired in cirrhosis. Establishing the relevance of depression, anxiety, alexithymia and cirrhosis stage on the patients%26apos; HRQoL. Sixty cirrhotics underwent a neuropsychological assessment, including ZUNG-SDS, STAI Y1-Y2 and TAS-20. Minimal hepatic encephalopathy (MHE) was detected by PHES, HRQoL by Short-Form-36 (SF-36). Depression was detected in 34 patients (57 %, 95%CI = 44-70 %), state-anxiety in 16 (27 %, 95%CI = 15-38 %), trait-anxiety in 17 (28 %, 95%CI = 17-40 %), alexithymia in 14 (31 % 95%CI = 16-46 %) and MHE in 22 (37 %, 95%CI = 24-49 %). Neuropsychological symptoms were unrelated to cirrhosis stage, hepatocellular carcinoma or MHE. A significant correlation was observed among psychological test scores and summary components of SF-36. At multiple linear regression analysis including Child-Pugh and MELD scores, previous-HE and the psychological test scores as possible covariates, alexithymia and depression as well as to the Child-Pugh score were significantly related to the SF-36 mental component; while trait-anxiety was the only variable significantly and independently related to the SF-36 physical component. Depression, state and trait-anxiety and alexithymia symptoms are frequent in cirrhotics and are among the major determinants of the altered HRQoL.

• 出版日期2013-6