Autoantibody responses to nodal and paranodal antigens in chronic inflammatory neuropathies

作者：Mathey E K; Garg N; Park S B; Nguyen T; Baker S; Yuki N; Yiannikas C; Lin C S; Spies J M; Ghaoui R; Barnett M H; Vucic S; Pollard J D; Kiernan M C

来源：Journal of Neuroimmunology, 2017, 309: 41-46.

DOI：10.1016/j.jneuroim.2017.05.002

• Chronic inflammatory demyelinating polyneuropathy
• Multifocal motor neuropathy
• Neurofascin
• Contactin
• Gliomedin
• Autoantibody

Autoantibodies to nodal/paranodal proteins have been reported in patients with chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN). To determine the frequency of anti-paranodal antibodies in our cohort of CIDP patients and to validate the presence anti-nodal antibodies in MMN, sera were screened for IgG against human neurofascin 155, contactin-1, neurofascin 186 and gliomedin using ELISA. In CIDP patients, 7% were anti-NF155 IgG(4) positive and 7% were anti-CNTN1 IgG(4) positive. Positive results were confirmed using cell based assays and indirect immunofluorescence on teased nerve fibres. We did not detect IgG autoantibodies against these nodal/paranodal antigens in MMN patients.

• 出版日期2017-8-15