Aqueous humor dynamics in inbred rhesus monkeys with naturally occurring ocular hypertension

作者：Toris Carol B^*; Risma Justin M; Gonzales Martinez Janis; McLaughlin Marsha A; Dawson William W

来源：Experimental Eye Research, 2010, 91(6): 860-865.

DOI：10.1016/j.exer.2010.09.011

• aqueous humor dynamics
• intraocular pressure
• rhesus monkey
• glaucoma

This study evaluates aqueous humor dynamics in rhesus monkeys from the University of Florida inbred colony with ocular normotension and naturally occurring ocular hypertension. Eight monkeys with untreated intraocular pressures (IOPs) of less than 18 mmHg in one eye (ONT group) and seven with untreated 10Ps of greater than or equal to 18 mmHg in one eye (OHT group) were included in the study. Assessments included central cornea thickness by ultrasound pachymetry,IOP by tonometry, aqueous flow and outflow facility by fluorophotometry, and uveoscleral outflow by mathematical calculation. Animals were sedated with ketamine for all measurements. Values from the two eyes of each animal were averaged, with the exception of one animal that had only one good eye. Comparisons between groups were made by Student's two-tailed unpaired t-tests. Compared to the ONT group, the OHT group had higher IOPs at all times measured (4:00 PM the day before the study, 21.2 +/- 6.5 versus 14.4 +/- 1.5 mmHg, p = 0.01; 9:00 AM the day of the study, 20.7 +/- 6.6 versus 14.8 +/- 1.2 mmHg, p = 0.03; 11:00 AM the day of the study, 16.0 +/- 1.6 versus 13.3 +/- 2.9 mmHg, p = 0.05) and lower aqueous flow (2.12 +/- 0.40 versus 4.54 +/- 1.11 mu l/min, p = 0.0001), outflow facility (0.17 +/- 0.10 versus 0.33 +/- 0.07 mu l/min/mmHg, p = 0.01) and uveoscleral outflow (p < 0.05). The elevated IOP in inbred Florida rhesus monkeys is a result of significantly reduced outflow facility and uveoscleral outflow.

• 出版日期2010-12