A preliminary investigation of Beta-hCG expression in patients with osteosarcoma

作者：Masrouha K Z; Khattab R; Tawil A; Abdallah A; Saghieh S; Haidar R; Abboud M; Khoury N J^*

来源：Journal of Bone and Joint Surgery-British Volume, 2012, 94B(3): 419-424.

DOI：10.1302/0301-620X.94B3.27679

There are eight reported cases in the literature of osteosarcomas secreting beta-hCG. Our primary aim was to investigate the rate of beta-hCG expression in osteosarcoma and attempt to understand the characteristics of osteosarcomas that secrete beta-hCG. We reviewed 37 histopathology slides (14 biopsies and 23 surgical specimens) from 32 patients with osteosarcoma. The slides were retrospectively stained for beta-hCG expression. Patient and tumour characteristics, including age, gender, tumour location, subtype, proportion of necrosis, presence of metastases and recurrence were recorded. A total of five of the 32 tumours were found to be positive for beta-hCG expression (one strongly and four weakly). This incidence of this expression was found in tumours with poor histological response to neoadjuvant chemotherapy. %26lt;br%26gt;The use of beta-hCG expression as a diagnostic, prognostic or follow-up marker is questionable and needs further investigation with a larger sample size.

• 出版日期2012-3