Age and Expression of CD163 and Colony-Stimulating Factor 1 Receptor (CD115) Are Associated With the Biological Behavior of Central Giant Cell Granuloma

作者：Kahn Adrian^*; Chaushu Gavriel; Ginene Lana; Vered Marilena

来源：Journal of Oral and Maxillofacial Surgery, 2017, 75(7): 1414-1424.

DOI：10.1016/j.joms.2017.01.001

Purpose: Central giant cell granulomas (CGCGs) are clinically classified as nonaggressive (nA-CGCGs) and aggressive (A-CGCGs). However, histopathologically, all lesions feature spindle mononuclear cells (MCs) and multinuclear giant cells (GCs) in a hemorrhage-rich stroma. We aimed to investigate the presence of cells with a monocyte-or macrophage-related phenotype and, together with clinical variables, to examine their predictive potential for the biological behavior of CGCGs.
Patients and Methods: For our investigation, we implemented a retrospective cohort study. Sections were immunohistochemically stained for colony-stimulating factor 1 receptor (CSF-1R) (CD115), CD163, CD68, and nuclear factor kappa B. The clinical variables included age, gender, and location of lesions. Associations between immunostains, clinical variables, and CGCG aggressiveness were analyzed by the Wilcoxon (Mann-Whitney) exact test and t test. Significant variables were further analyzed by a logistic regression model followed by receiver operating characteristic (ROC) curve analysis for diagnostic sensitivity. Significance was set at P <.05.
Results: Patients with A-CGCGs (n = 36) were younger than those with nA-CGCGs (n = 31) (P =.002). Logistic regression showed that CD163-GC (beta = -0.870, P =.031) and CD115-MC (beta = -0.783, P =.027) had a significant protection effect (odds ratio, 0.419 [95% confidence interval, 0.190 to 0.925], and odds ratio, 0.457 [95% confidence interval, 0.229 to 0.913], respectively). ROC curve analysis showed that CD163-GC and CSF-1R (CD115)-MC combined were the best predictor in distinguishing nA-CGCGs from A-CGCGs (area under ROC curve, 0.814; P <.001). At the optimal cutoff value (0.408), sensitivity was 87% and specificity, 65%.
Conclusions: Increasing age and high expression of CD163-GC and CSF-1R (CD115)-MC can serve as significant predictors of nA-CGCGs. A functional link between CD163-GC and the characteristic areas of extravasation of erythrocytes is discussed.

• 出版日期2017-7