Health-related quality of life and its determinants in children and adolescents born with oesophageal atresia

作者：Peetsold M G^*; Heij H A; Deurloo J A; Gemke R J B J

来源：Acta Paediatrica, 2010, 99(3): 411-417.

DOI：10.1111/j.1651-2227.2009.01579.x

• Health-related quality of life
• Long-term follow-up
• Oesophageal atresia

Aim: Following surgical correction in the neonatal period, patients born with oesophageal atresia have significant co-morbidity, particularly in childhood. This study evaluates health-related quality of life and its determinants such as concomitant anomalies and the presence of respiratory and/or gastro-intestinal symptoms 6-18 years after repair of oesophageal atresia.
Methods: Parents of 24 patients with oesophageal atresia completed the child health questionnaire for parents and 37 patients completed the child form. Gastro-intestinal symptoms were assessed by a validated standardized reflux questionnaire. Results were compared with a healthy reference population.
Results: Parents as well as patients themselves scored significantly lower on the domain general health perception. According to parents, general health perception was negatively affected by age at follow-up and concomitant anomalies. Patients reported that reflux symptoms reduced general health perception.
Conclusion: In this first study describing health-related quality of life in children and adolescents born with oesophageal atresia, we demonstrated that general health remains impaired because of a high incidence of concomitant anomalies and gastrointestinal symptoms in patients with oesophageal atresia when compared with the healthy reference population.

• 出版日期2010-3