Aqua mediated synthesis of 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes and its in vitro study, explanation of the structure-activity relationships (SARs) as antibacterial agent

作者：Kidwai Mazaahir^*; Poddar Roona; Bhardwaj Saurav; Singh Satendra; Luthra Pratibha Mehta

来源：European Journal of Medicinal Chemistry, 2010, 45(11): 5031-5038.

DOI：10.1016/j.ejmech.2010.08.010

• 2-Amino-6-benzothiazol-2-ylsulfanyl-chromenes
• SAR
• Aqueous medium
• 2-Benzothiazolethiol
• Antibacterial activity

Multi-component reaction (MCR) involves coupling of p-bromophenol with 2-Benzothiazolethiol, malononitrile and substituted aldehydes in aqueous K(2)CO(3) as green base to synthesize 2-amino-6-benzothiazol-2-ylsulfanyl-chromenes. This multi-component reaction thus offers a higher yield and versatility in the preparation of densely functionalized oxygen heterocycles. The newly synthesized compounds were screened for their antibacterial activities against positive and gram negative pathogenic strains to bacteria. SAR analysis was performed to explore comprehensive structure activity relationships and a statistically reliable model to explain their antibacterial-activities.

• 出版日期2010-11