Associations between Tumor Necrosis Factor-alpha Polymorphisms and Risk of Psoriasis: A Meta-Analysis

作者：Zhuang, Le; Ma, Weiyuan; Cai, Daxing; Zhong, Hua; Sun, Qing^*

来源：PLos One, 2013, 8(12): e68827.

DOI：10.1371/journal.pone.0068827

• GENOME-WIDE ASSOCIATION
• PROMOTER POLYMORPHISMS
• ONSET PSORIASIS
• SUSCEPTIBILITY
• GENE
• ARTHRITIS
• VULGARIS
• DISEASE
• REGION
• HLA

Background: Tumor necrosis factor-alpha (TNF-alpha) may play an important role in the recalcitrant inflammatory and hyperproliferative dermatosis of psoriasis, and there may be a relationship between TNF-alpha polymorphisms and psoriasis risk.
Methods: We performed a meta-analysis to evaluate the associations between TNF-alpha polymorphisms and psoriasis. Electronic searches of Pubmed, Embase, and Web of Science were performed for all publications on the associations between TNF-alpha polymorphisms and psoriasis through September 26, 2012. The pooled odds ratios (ORs) with their 95% confidence interval (95% CIs) were calculated to assess the associations.
Results: Sixteen case-control studies with a total of 2,253 psoriasis cases and 1,947 controls on TNF-alpha 308 G/A polymorphism and fourteen studies on TNF-alpha 238 G/A polymorphism with 2,104 cases and 1,838 controls were finally included into the meta-analysis. Overall, TNF-alpha 308 G/A polymorphism was significantly associated with decreased risk of psoriasis under three genetic comparison models (for A versus G: fixed-effects OR 0.71, 95% CI 0.62-0.82, P < 0.001; for AG versus GG: fixed-effects OR 0.67, 95% CI 0.57-0.78, P < 0.001; for AA/AG versus GG: fixed-effects OR 0.67, 95% CI 0.58-0.78, P < 0.001). In addition, TNF-alpha 238 G/A polymorphism was associated with increased risk of psoriasis under three genetic models (for A versus G: fixed-effects OR 2.46, 95% CI 2.04-2.96, P < 0.001; for AG versus GG: fixed-effects OR 2.69, 95% CI 2.20-3.28, P < 0.001; for AA/AG versus GG: fixed-effects OR 2.68, 95% CI 2.20-3.26, P < 0.001). Subgroup analysis by ethnicity identified a significant association between TNF-alpha 308 G/A polymorphism and decreased risk of psoriasis in both Caucasians and Asians and a significant association between TNF-alpha 238 G/A polymorphism and increased risk of psoriasis in Caucasians.
Conclusions: The meta-analysis suggests that TNF-alpha 308 G/A polymorphism is associated with decreased risk of psoriasis, while TNF-alpha 238 G/A is associated with increased risk of psoriasis.

• 出版日期2013-12-4
• 单位山东大学