Antidepressant-like effect of m-trifluoromethyl-diphenyl diselenide in the mouse forced swimming test involves opioid and serotonergic systems

作者：Bruening Cesar Augusto; Guerra Souza Ana Cristina; Gai Bibiana Mozzaquatro; Zeni Gilson; Nogueira Cristina Wayne^*

来源：European Journal of Pharmacology, 2011, 658(2-3): 145-149.

DOI：10.1016/j.ejphar.2011.02.039

• Organoselenium
• Antidepressant-like
• Serotonin
• Opioid
• Depression
• Selenium

Serotonergic and opioid systems have been implicated in major depression and in the action mechanism of antidepressants. The organoselenium compound m-trifluoromethyl-diphenyl diselenide (m-CF(3)-PhSe)(2) shows antioxidant and anxiolytic activities and is a selective inhibitor of monoamine oxidase A activity. The present study was designed to investigate the antidepressant-like effect of (m-CF(3)-PhSe)(2) in female mice, employing the forced swimming test. The involvement of the serotonergic and opioid systems in the antidepressant-like effect of (m-CF(3)-PhSe)(2) was appraised. (m-CF(3)-PhSe)(2) at doses of 50 and 100 mg/kg ( p.o.) exhibited antidepressant-like action in the forced swimming test. The effect of (m-CF3-PhSe)2 (50 mg/kg p.o.) was prevented by pretreatment of mice with WAY100635 (0.1 mg/kg, s.c. a selective 5-HT(1A) receptor antagonist), ritanserin (4 mg/kg, i.p., a non-selective 5HT(2A/2C) receptor antagonist), ondansetron (1 mg/kg, i.p., a selective 5-HT(3) receptor antagonist) and naloxone (1 mg/kg, i.p., a non-selective antagonist of opioid receptors). These results suggest that (m-CF(3)-PhSe)(2) produced an antidepressant-like effect in the mouse forced swimming test and this effect seems most likely to be mediated through an interaction with serotonergic and opioid systems.

• 出版日期2011-5-11