High Risk for Essential Hypertension in Males Conferred by g.15241A > G Polymorphism in Intron 3 of AGT Gene

作者：Padma Gunda; Bhupatiraju Charita; Srinivas Bhyravavajhala; Padma Tirunilai^*

来源：Clinical and Experimental Hypertension, 2013, 35(2): 108-111.

DOI：10.3109/10641963.2012.702828

• polymorphism
• intron
• AGT gene
• risk
• males

A total of 180 hypertensive and 188 normotensive subjects were studied for demographic features and for variations in exon 4 including exon-intron boundary of AGT gene using single-strand conformation polymorphism analysis. Sequencing of the samples showing mobility shift revealed a single-nucleotide polymorphism variant g.15241A>G in intron 3 of the gene. The polymorphism was consistent with Hardy-Weinberg equilibrium in both the cases and the controls. Although the genotype distribution and allele frequencies did not differ significantly in general, high risk was observed for males with G allele (OR = 2.08; 95% CI = 1.02-4.21; P = .04). Similar results were obtained when the genotypes were tested in dominant model wherein G allele carriers were found to be at twofold risk for developing essential hypertension (OR = 2.09; 95% CI = 0.99-4.41; P = 0.05). This report is the first one in the literature showing association of g.15241A>G polymorphism with a clinical condition.

• 出版日期2013
• 单位河北医科大学