Asymmetric hydrogenation of alpha,beta-unsaturated carboxylic acids catalyzed by ruthenium(II) complexes of spirobifluorene diphosphine (SFDP) ligands

作者：Cheng Xu; Xie Jian Hua; Li Sheng; Zhou Qi Lin^*

来源：Advanced Synthesis & Catalysis, 2006, 348(10-11): 1271-1276.

DOI：10.1002/adsc.200606065

• asymmetric hydrogenation
• diphosphanes
• P ligands
• ruthenium
• spirobifluorenes
• alpha,beta-unsaturated
• carboxylic acids

The ruthenium diacetate complexes ligated by chiral spirobifluorene diphosphines (SFDP) were very effective catalysts for the asymmetric hydrogenation of tiglic acid derivatives and alpha-methylcinnamic acid derivatives with high activities and excellent enantioselectivities (up to 98 % ee). The alpha-aryloxybutenoic acids can also be hydrogenated by these catalysts to provide the corresponding saturated alpha-aryloxybutanoic acids in high yields (89-93 %) and enantioselectivities (up to 95 % ee). In this reaction, the SFDP ligand with para-methyl groups on the P-phenyl rings gave the best results.

• 出版日期2006-7
• 单位南开大学