Unexpected formation of 6,7-dihydrobenzo[4',5']imidazo-[1',2':1,6]pyrimido[5,4-a]indolizine derivative in the alkylation of 2-amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl)indolizine

作者：Saraeva T A^*; Khoroshilov G E; Brovarets V S; Zubatyuk R I; Shishkin O V

来源：Russian Journal of General Chemistry, 2011, 81(10): 2172-2175.

DOI：10.1134/S1070363211100227

An attempt to effect exhaustive alkylation of 2-amino-1-(benzimidazol-2-yl)-3-(4-methoxybenzoyl) indolizine with alkyl iodides in boiling acetone led to the formation of 6,6-dimethyl-8-(4-methoxybenzoyl)-6,7-dihydrobenzo[4',5']imidazo[1',2': 1,6]pyrimido[5,4-a]indolizine instead of expected N-alkyl derivatives. The product structure was proved by X-ray analysis.

• 出版日期2011-10