A-type procyanidins from litchi pericarp ameliorate hyperglycaemia by regulating hepatic and muscle glucose metabolism in streptozotocin (STZ)-induced diabetic mice fed with high fat diet

作者：Li, Xiaopeng; Sui, Yong; Li, Shuyi; Xie, Bijun; Sun, Zhida^*

来源：Journal of Functional Foods, 2016, 27: 711-722.

DOI：10.1016/j.jff.2016.08.010

• A-type procyanidins
• Litchi pericarp
• Diabetes
• Hypoglycaemic effect

A-type procyanidins is rich in litchi pericarp. This study evaluated the prevention and anti diabetic effect of A-type oligomeric procyanidins (A-OPC). The results showed A-OPC was more effective than B-type oligomeric procyanidins (B-OPC) of lotus seedpod. AMP activated protein ldnase (AMPK) was activated in liver and skeletal muscle. The protein levels of glucokinase (GK), glucose transporter type 2 (GLUT2, in liver), glucose transporter type 4 (GLUT4, in skeletal muscle) and insulin receptor a (INSR) improved significantly with treatment of A-OPC or B-OPC (p < 0.05). Furthermore, the glycolytic key gene expressions of phosphofructokinase (PFK), pyruvate kinase (PK) in liver and skeletal muscle and pyruvate dehydrogenase (PDH) in skeletal muscle were notably up-regulated, while gene expressions, rate-limiting enzymes of gluconeogenesis, of phosphoenolpyruvate carboxykinase (PEPCK) and glucose-6-phosphatase (G-6-Pase) were down-regulated. Both A-OPC and B-OPC improved glucose homeostasis by inhibiting the glucose production in liver, regulating the expression of proteins involved in glucose transport system and increasing glycolysis.

• 出版日期2016-12
• 单位华中农业大学; 武汉轻工大学