Measuring brain oxygenation in humans using a multiparametric quantitative blood oxygenation level dependent MRI approach

作者：Christen Thomas^*; Schmiedeskamp Heiko; Straka Matus; Bammer Roland; Zaharchuk Greg

来源：Magnetic Resonance in Medicine, 2012, 68(3): 905-911.

DOI：10.1002/mrm.23283

• blood oxygenation level dependent
• cerebral blood volume
• blood oxygen saturation
• brain

Quantitative blood oxygenation level dependent approaches have been designed to obtain quantitative oxygenation information using MRI. A mathematical model is usually fitted to the time signal decay of a gradient-echo and spin-echo measurements to derive hemodynamic parameters such as the blood oxygen saturation or the cerebral blood volume. Although the results in rats and human brain have been encouraging, recent studies have pointed out the need for independent estimation of one or more variables to increase the accuracy of the method. In this study, a multiparametric quantitative blood oxygenation level dependent approach is proposed. A combination of arterial spin labeling and dynamic susceptibility contrast methods were used to obtain quantitative estimates of cerebral blood volume and cerebral blood flow. These results were combined with T?2* and T2 measurements to derive maps of blood oxygen saturation or cerebral metabolic rate of oxygen. In 12 normal subjects, a mean cerebral blood volume of 4.33 +/- 0.7%, cerebral blood flow of 43.8 +/- 5.7 mL/min/100 g, blood oxygen saturation of 60 +/- 6% and cerebral metabolic rate of oxygen 157 +/- 23 mu mol/100 g/min were found, which are in agreement with literature values. The results obtained in this study suggest that this methodology could be applied to study brain hypoxia in the setting of pathology. Magn Reson Med, 2012.

• 出版日期2012-9