Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity

作者：Orhan Hilmi^*; Sahin Altan; Sahin Gonul; Aypar Ulku; Vermeulen Nico P E

来源：Biomarkers, 2013, 18(1): 73-81.

DOI：10.3109/1354750X.2012.737026

• Aldehydes
• acetone
• dityrosine
• tubular damage
• clinical markers

Objective: To investigate whether lipid and protein oxidation products are elevated and correlated with routine clinical markers of hepatic and renal function in patients anesthetized with halothane, isoflurane, or sevoflurane. %26lt;br%26gt;Methods: Urine and blood samples were collected from patient groups. Excretion of aldehydes, acetone, and o,o%26apos;-dityrosine was measured before and after anesthesia. Blood samples were analysed for clinical markers. %26lt;br%26gt;Results: Urinary concentrations of aldehydes, acetone, o,o%26apos;-dityrosine and glucose were significantly increased after anesthesia in halothane and sevoflurane groups earlier than clinical markers. Significant correlations were found in sevoflurane group. %26lt;br%26gt;Conclusion: Lipid and protein oxidation contributes to subclinical sevoflurane nephrotoxicity. Oxidation products may serve as early biomarkers.

• 出版日期2013-2