Low-Molecular-Weight Hydrophilic and Lipophilic Antioxidants in Nonmelanoma Skin Carcinomas and Adjacent Normal-Looking Skin

作者：Grammenandi Konstantina; Kyriazi Maria; Katsarou Katsari Alexandra; Papadopoulos Othon; Anastassopoulou Ioanna; Papaioannou Georgios T; Sagriotis Alexandros; Rallis Michail^*; Maibach Howard I

来源：Skin Pharmacology and Physiology, 2016, 29(6): 324-331.

DOI：10.1159/000453456

• Low-molecular-weight antioxidants
• Skin cancer
• Ascorbic acid
• Uric acid
• alpha-Tocopherol
• beta-Carotene
• Ubiquinol

Low-molecular-weight antioxidants are some of the most efficient agents of the skin defense mechanism against environmental factors, such as cosmic rays, smoke, and pollutants. The total skin concentrations of hydrophilic ascorbic and uric acids, as well as lipophilic alpha-tocopherol, beta-carotene, and ubiquinol-10 antioxidants were determined by an HPLCEC detector from 18 biopsies of human nonmelanoma skin carcinomas and 18 biopsies from skin areas adjacent to carcinomas. No significant differences in the concentrations of lipophilic antioxidants in both carcinomas and normal-looking skin areas adjacent to carcinomas were observed. On the contrary, ascorbic and uric acid concentrations were found to be 18 and 36% lower in carcinomas than in normal-looking skin areas, respectively. No statistical significance was observed between antioxidant concentrations and age, sex, phototype, profession, site of tumor, frequency, and time of UV light exposure either. Accordingly the antioxidant concentrations in both cancerous skin and adjacent normal-looking areas were found to be much higher than in normal skin, in contrast to literature data.

• 出版日期2016