Association Between TP53 Gene Codon 72 Polymorphism and Acute Myeloid Leukemia Susceptibility: Evidence Based on a Meta-Analysis

作者：Ruan Xiao Lan; Li Sheng; Geng Peiliang; Zeng Xian Tao; Yu Guo Zheng; Meng Xiang Yu; Gao Qing Ping^*; Ao Xu Bin

来源：MEDICAL SCIENCE MONITOR, 2015, 21: 3048-3053.

DOI：10.12659/MSM.894625

• Genes, p53
• Leukemia, Myeloid
• Meta-Analysis
• Polymorphism, Genetic

Background: Many studies have reported that the p53 codon 72 polymorphism is associated with acute myeloid leukemia (AML) susceptibility; however, the conclusions are inconsistent. Therefore, we performed this meta-analysis to obtain a more precise result.
Material/Methods: We searched PubMed to identify relevant studies, and 6 published case-control studies were retrieved, including 924 AML patients and 3832 controls. Odds ratio (OR) with corresponding 95% confidence interval (95% CI) was applied to assess the association between p53 codon 72 polymorphism and AML susceptibility. The meta-analysis was performed with Comprehensive Meta-Analysis software, version 2.2.
Results: Overall, no significant association between p53 codon 72 polymorphism and AML susceptibility was found in this meta-analysis (Pro vs. Arg: OR=0.94, 95% CI=0.81-1.10; Pro/Pro vs. Arg/Arg: OR=0.93, 95% CI=0.71-1.22; Arg/Pro vs. Arg/Arg: OR=0.79, 95% CI=0.55-1.13; (Pro/Pro + Arg/Pro) vs. Arg/Arg: OR=0.84, 95% CI=0.62-1.13; Pro/Pro vs. (Arg/Arg + Arg/Pro): OR=1.06, 95% CI=0.83-1.35). Similar results were also found in stratified analysis according to ethnicity and source of controls.
Conclusions: Our meta-analysis demonstrates that p53 codon 72 polymorphism may not be a risk factor for AML, which should be verified in future studies.

• 出版日期2015-10-9
• 单位武汉大学