Antecedents of Perinatal Cerebral White Matter Damage With and Without Intraventricular Hemorrhage in Very Preterm Newborns

作者：Logan J Wells^*; Westra Sjirk J; Allred Elizabeth N; O' Shea T Michael; Kuban Karl; Paneth Nigel; Leviton Alan

来源：Pediatric Neurology, 2013, 49(2): 88-96.

DOI：10.1016/j.pediatrneurol.2013.03.018

BACKGROUND: Isolated periventricular leukomalacia, defined as periventricular leukomalacia unaccompanied by intraventricular hemorrhage, is reportedly increased in newborns with systemic hypotension and in infants who received treatment for systemic hypotension or a patent ductus arteriosus. METHODS: This study sought to determine if the risk profile of one or more hypoechoic lesions unaccompanied by intraventricular hemorrhage, our surrogate for isolated periventricular leukomalacia, differs from that of one or more hypoechoic lesions preceded or accompanied by intraventricular hemorrhage. We compared extremely preterm infants (i.e., gestation 23-27 weeks) with each of these entities to 885 extremely preterm infants who had neither an isolated hypoechoic lesion nor a hypoechoic lesion preceded or accompanied by intraventricular hemorrhage. RESULTS: The risk of a hypoechoic lesion with intraventricular hemorrhage (N = 61) was associated with gestation %26lt;25 weeks, high Score for Acute Neonatal Physiology, early recurrent or prolonged acidemia, analgesic exposure, and mechanical ventilation 1 week after birth. CONCLUSIONS: In this large, multicenter sample of extremely low gestational age newborns, the risk profile of a hypoechoic lesion unaccompanied by intraventricular hemorrhage differed from that of a hypoechoic lesion with intraventricular hemorrhage. This suggests that hypoechoic lesions accompanied or preceded by intraventricular hemorrhage (our surrogate for periventricular hemorrhagic infarction) may have a different causal pathway than hypoechoic lesions without intraventricular hemorrhage, our surrogate for periventricular leukomalacia. 2013 Elsevier Inc.

• 出版日期2013-8