Antioxidant and NF-kappa B inhibitory constituents isolated from Morchella esculenta

作者：Kim Jeong Ah; Lau Edward; Tay David; De Blanco Esperanza J Carcache^*

来源：Natural Product Research, 2011, 25(15): 1412-1417.

DOI：10.1080/14786410802425746

• Morchella esculenta
• antioxidants
• NF-kappa B
• sterols

Morchella esculenta Pers. (Morchellaceae) was investigated for its antioxidant activity by measuring the intracellular reactive oxygen species in HT-29 colon cancer cells. The methylene chloride extract, which showed the highest antioxidant activity, led to the isolation of four fungal sterols, 1-4, and trilinolein (5), in addition to methyl myristate (6), 1-linoleoylglycerol (7), and ceramide (8). The isolated compounds were identified through the analysis of various spectroscopic methods. In the hydroxyl radical assay, 5-dihydroergosterol exhibited significant antioxidant activity. All compounds isolated were also tested using an enzyme-based Elisa NF-kappa B assay. Fungal sterols and trilinolein showed significant inhibition of NF-kappa B activation in the NF-kappa B assay.

• 出版日期2011