A simple one-pot synthesis of 2,6-disubstituted 4-(polyfluoroalkyl)pyridines and -pyrimidines by reaction of 2-polyfluoroalkylchromones with aromatic methyl ketimines and amidines

作者：Sosnovskikh VY^*; Usachev BI; Yu A; Barabanov MA

来源：Synthesis, 2004, (6): 942-948.

DOI：10.1055/s-2004-822321

• 2-polyfluoroalkylchromones
• ketimines
• amidines
• 4-polyfluoroalkylpyridines and -pyrimidines

The reaction of 2-polyfluoroalkylchromones with ketimines, derived from aromatic methyl ketones and isopropylamine, gives 2,6-diaryl-4-polyfluoroalkylpyridines in moderate to low yields. Benzamidine and guanidine also react with 2-polyfluoroalkylchromones to afford the corresponding 2,6-disubstituted 4-polyfluoroalkylpyrimidines.

• 出版日期2004-4-22