Anaerobic function of CNS white matter declines with age

作者：Hamner Margaret A; Moeller Thomas; Ransom Bruce R^*

来源：Journal of Cerebral Blood Flow and Metabolism, 2011, 31(4): 996-1002.

DOI：10.1038/jcbfm.2010.216

• anoxia
• CNS axon
• cyanide
• energy metabolism
• glycolysis

The mammalian central nervous system (CNS) is generally believed to be completely dependent on the presence of oxygen (O(2)) to maintain energy levels necessary for excitability. However, previous studies on CNS white matter (WM) have shown that a large subset of CNS-myelinated axons of mice aged 4 to 6 weeks remains excitable in the absence of O2. We investigated whether this surprising WM tolerance to anoxia varied with age. Acutely isolated mouse optic nerve (MON), a purely myelinated WM tract, was studied electrophysiologically. Excitability in the MONs from 1-month-, 4-month-, and 8-month-old mice was assessed quantitatively as the area under the supramaximal compound action potential (CAP). Anoxia-resistant WM function declined with age. After 60 minutes of anoxia, similar to 23% of the CAP remained in 1-month-old mice, 8% in 4-month-old mice, and similar to 0 in the 8-month-old group. Our results indicated that although some CNS axons function anaerobically in young adult animals, they lose this ability in later adulthood. This finding may help explain the clinical impression that favorable outcome after stroke and other brain injuries declines with age. Journal of Cerebral Blood Flow & Metabolism (2011) 31, 996-1002; doi: 10.1038/jcbfm.2010.216; published online 22 December 2010

• 出版日期2011-4